Article
A neuronal GPCR is critical for the induction of the heat shock response in the nematode C. elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Apr 2013
Maman Moria, Carvalhal Marques Filipa, Volovik Yuli, Dubnikov Tatyana, Bejerano-Sagie Michal, Cohen Ehud
Abstract excerpt
In the nematode Caenorhabditis elegans, the heat shock response (HSR) is regulated at the organismal level by a network of thermosensory neurons that senses elevated temperatures and activates the HSR in remote tissues. Which neuronal receptors are required for this signaling mechanism and in which neurons they function are largely unanswered questions. Here we used worms that were engineered to exhibit RNA...
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