Article
Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons.
Science (New York, N.Y.) - 9 May 2008
Prahlad Veena, Cornelius Tyler, Morimoto Richard I
Abstract excerpt
Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we...
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