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Article

CST does not evict elongating telomerase but prevents initiation by ssDNA binding.

Nucleic acids research - 18 Nov 2021

Zaug Arthur J, Lim Ci Ji, Olson Conner L, Carilli Maria T, Goodrich Karen J, Wuttke Deborah S, Cech Thomas R

Abstract excerpt

The CST complex (CTC1-STN1-TEN1) has been shown to inhibit telomerase extension of the G-strand of telomeres and facilitate the switch to C-strand synthesis by DNA polymerase alpha-primase (pol α-primase). Recently the structure of human CST was solved by cryo-EM, allowing the design of mutant proteins defective in telomeric ssDNA binding and prompting the reexamination of CST inhibition of telomerase. The...

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Identifiers

PMID: 34718732
DOI: 10.1093/nar/gkab942
PMCID: PMC8599947

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Human CST Prefers G-Rich but Not Necessarily Telomeric SequencesSemantic proximity Read ↗

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.Semantic proximity Read ↗

CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cellsSemantic proximity Read ↗

The cryo-EM structure of human CST reveals a two-megadalton decameric assembly bound to telomeric DNASemantic proximity Read ↗

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