Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reconstitution of a telomeric replicon organized by CST

13 Jul 2022

Abstract excerpt

Abstract Telomeres, the natural ends of linear chromosomes, comprise repeat-sequence DNA and associated proteins 1 . Replication of telomeres allows continued proliferation of human stem cells and immortality of cancer cells 2 . This replication requires telomerase 3 extension of the single-stranded DNA (ssDNA) of the telomeric G-strand ((TTAGGG) n ); the synthesis of the complementary C-strand ((CCCTAA) n ) is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to DNA and Nucleic Acid Chemistry
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35831508
DOI: 10.1038/s41586-022-04930-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reconstitution of a telomeric replicon organized by CSTPMID 35831508Read ↗

CTC1-mediated C-strand fill-in is an essential step in telomere length maintenanceSemantic proximity Read ↗

Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-InSemantic proximity Read ↗

Mammalian CST averts replication failure by preventing G-quadruplex accumulationSemantic proximity Read ↗

Emerging roles of CST in maintaining genome stability and human disease.Semantic proximity Read ↗

Unravelling the Intricacies of Telomere Replication: A Molecular ConundrumSemantic proximity Read ↗

CST does not evict elongating telomerase but prevents initiation by ssDNA binding.Semantic proximity Read ↗

The yeast CST and Polα/primase complexes act in concert to ensure proper telomere maintenance and protectionSemantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

The human CST complex is a terminator of telomerase activitySemantic proximity Read ↗

Extrachromosomal telomere DNA derived from excessive strand displacementsSemantic proximity Read ↗

CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cellsSemantic proximity Read ↗

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.