Article
Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae formation.
Molecular oncology - 1 Jan 2022
Kagawa Yoshiteru, Umaru Banlanjo Abdulaziz, Kanamori Masayuki, Zama Ryo, Shil Subrata Kumar, Miyazaki Hirofumi, Kobayashi Shuhei, Wannakul Tunyanat, Yang Shuhan, Tominaga Teiji, Owada Yuji
Abstract excerpt
Isocitrate dehydrogenase 1 (IDH1) is a key enzyme in cellular metabolism. IDH1 mutation (IDH1mut) is the most important genetic alteration in lower grade glioma, whereas glioblastoma (GB), the most common malignant brain tumor, often has wild-type IDH1 (IDH1wt). Although there is no effective treatment yet for neither IDH1wt nor IDHmut GB, it is important to note that the survival span of IDH1wt GB patients is...
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