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Article

Mutant IDH1 inhibits PI3K/Akt signaling in human glioma.

Cancer - 15 Aug 2014

Birner Peter, Pusch Stefan, Christov Christo, Mihaylova Stiliana, Toumangelova-Uzeir Kalina, Natchev Sevdalin, Schoppmann Sebastian F, Tchorbanov Andrey, Streubel Berthold, Tuettenberg Jochen, Guentchev Marin

Abstract excerpt

BACKGROUND: Recently, isocitrate dehydrogenase 1 (IDH1) was identified as a major participant in glioma pathogenesis. At present, the enzymatic activity of the protein has been the main topic in investigating its physiological function, but its signaling pathway allocation was unsuccessful. Interestingly, proteins regulated by phosphoinositide 3-kinase (PI3K)/Akt signaling, are among the top downregulated genes...

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Source

Identifiers

PMID: 24771584
DOI: 10.1002/cncr.28732

Genes

IDH1
IDH2
PDPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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