Article

Mutant IDH impairs chromatin binding by PDGFB to promote chromosome instability

2025-02-25

Abstract excerpt

Non-canonical roles for growth factors in the nucleus have been previously described, but their mechanism of action and biological roles remain enigmatic. Platelet-derived growth factor B (PDGFB) can drive formation of low-grade glioma and here we show that it localizes to the nucleus of human glioma cells where it binds chromatin to preserve genome stability and cell lineage. Failure of PDGFB to localize to the n...

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Literature Corpus work: 9ad9d4f8-85de-5266-b8cb-88a647177a75
DOI: 10.1101/2025.02.20.639365

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