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Article

Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes.

The Journal of clinical investigation - 2 Apr 2018

Ullah Ikram, Karthik Govindasamy-Muralidharan, Alkodsi Amjad, Kjällquist Una, Stålhammar Gustav, Lövrot John, Martinez Nelson-Fuentes, Lagergren Jens, Hautaniemi Sampsa, Hartman Johan, Bergh Jonas

Abstract excerpt

Metastatic breast cancers are still incurable. Characterizing the evolutionary landscape of these cancers, including the role of metastatic axillary lymph nodes (ALNs) in seeding distant organ metastasis, can provide a rational basis for effective treatments. Here, we have described the genomic analyses of the primary tumors and metastatic lesions from 99 samples obtained from 20 patients with breast cancer. Our...

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Identifiers

PMID: 29480816
DOI: 10.1172/JCI96149
PMCID: PMC5873882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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