Article
Increased expression of Filaggrin and Claudin-1 in the ocular surface of patients with atopic dermatitis.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Feb 2022
Callou T M P, Orfali R L, Sotto M N, Pereira N V, Zaniboni M C, Aoki V, Brito M P, Matsuda M, Santo R M
Abstract excerpt
BACKGROUND: Atopic dermatitis (AD) is an itchy, chronic and inflammatory skin condition, with dysfunctional immune response and skin barrier defects. Reduction of filaggrin (FLG) and tight junctions (TJ) proteins, such as claudin-1 (CLDN-1), expression in cutaneous epithelial barrier is remarkable in AD pathogenesis. Ocular involvement occurs in approximately 40% of AD patients leading to changes in the structure...
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