Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Correlation of age-of-onset of Atopic Dermatitis with Filaggrin loss-of-function variant status.

Scientific reports - 17 Feb 2020

Smieszek S P, Welsh S, Xiao C, Wang J, Polymeropoulos C, Birznieks G, Polymeropoulos M H

Abstract excerpt

The genetic background of Atopic Dermatitis (AD) with chronic pruritus is complex. Filaggrin (FLG) is an essential gene in the epidermal barrier formation s. Loss-of-function (LOF) variants in FLG associated with skin barrier dysfunction constitute the most well-known genetic risk factor for AD. In this study, we focused on the frequency and effect of FLG loss-of-function variants in association with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Disease
Share to Dermatitis, Atopic
Share to Filaggrin Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Function Mutation

Share to Permeability

Share to Pruritus

Share to S100 Proteins

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 32066784
DOI: 10.1038/s41598-020-59627-7
PMCID: PMC7026049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Correlation of age-of-onset of Atopic Dermatitis with Filaggrin loss-of-function variant status.PMID 32066784Read ↗

Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort.Semantic proximity Read ↗

Genetics of Atopic Dermatitis: From DNA Sequence to Clinical RelevanceSemantic proximity Read ↗

Filaggrin loss-of-function mutations are not associated with atopic dermatitis that develops in late childhood or adulthood.Semantic proximity Read ↗

An update on the genetics of atopic dermatitis: scratching the surface in 2009.Semantic proximity Read ↗

Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects.Semantic proximity Read ↗

Loss-of-function mutations within the filaggrin gene and atopic dermatitis.Semantic proximity Read ↗

Unravelling the complex genetic background of atopic dermatitis: from genetic association results towards novel therapeutic strategies.Semantic proximity Read ↗

Trying to understand the genetics of atopic dermatitis.Semantic proximity Read ↗

The Genetics and Epigenetics of Atopic Dermatitis-Filaggrin and Other Polymorphisms.Semantic proximity Read ↗

Clinical characteristics of Korean patients with filaggrin-related atopic dermatitis.Semantic proximity Read ↗

Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.Semantic proximity Read ↗

Genetics of atopic dermatitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.