Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare germline variants in childhood cancer patients suspected of genetic predisposition to cancer.

Genes, chromosomes & cancer - 1 Feb 2022

Sylvester Dianne E, Chen Yuyan, Grima Natalie, Saletta Federica, Padhye Bhavna, Bennetts Bruce, Wright Dale, Krivanek Michael, Graf Nicole, Zhou Li, Catchpoole Daniel, Kirk Judy, Latchoumanin Olivier, Qiao Liang, Ballinger Mandy, Thomas David, Jamieson Robyn, Dalla-Pozza Luciano, Byrne Jennifer A

Abstract excerpt

Identification of cancer-predisposing germline variants in childhood cancer patients is important for therapeutic decisions, disease surveillance and risk assessment for patients, and potentially, also for family members. We investigated the spectrum and prevalence of pathogenic germline variants in selected childhood cancer patients with features suggestive of genetic predisposition to cancer. Germline DNA was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Exome Sequencing

Share to Germ-Line Mutation

Share to Infant

Share to Infant, Newborn

Share to Neoplasms

Source

Identifiers

PMID: 34687117
DOI: 10.1002/gcc.23006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare germline variants in childhood cancer patients suspected of genetic predisposition to cancer.PMID 34687117Read ↗

Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer.Semantic proximity Read ↗

Germline mutations in cancer predisposition genes among pediatric patients with cancer and congenital anomalies.Semantic proximity Read ↗

Investigation of clinically relevant germline variants detected by next-generation sequencing in patients with childhood cancer: a review of the literatureSemantic proximity Read ↗

The genetic era of childhood cancer: Identification of high-risk patients and germline sequencing approaches.Semantic proximity Read ↗

Pathogenic Variants in Adult-Onset Cancer Predisposition Genes in Pediatric Cancer: Prevalence and Impact on Tumor Molecular Features and Clinical Management.Semantic proximity Read ↗

Pediatric Oncology Patients With Germline Pathogenic Variants in Adult-Onset Cancer Predisposition Genes.Semantic proximity Read ↗

Prevalence and Clinical Significance of Adult-Onset Cancer Predisposition Variants in Pediatric OncologySemantic proximity Read ↗

Childhood Cancer Predisposition and Evolutionary Constraints: Novel Lessons from Germline Genomes from 1,127 Children with CancerSemantic proximity Read ↗

Cancer Predisposition Syndromes in Children: Who, How and When Should Genetic Studies Be Considered?Semantic proximity Read ↗

Germline Mutations in Predisposition Genes in Pediatric CancerSemantic proximity Read ↗

Germline Predisposition to Pediatric Cancer, from Next Generation Sequencing to Medical CareSemantic proximity Read ↗

Cancer Predisposition Syndromes in Children: Who, How, and When Should Genetic Studies Be Considered?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.