Article

Prevalence and Clinical Significance of Adult-Onset Cancer Predisposition Variants in Pediatric Oncology

2026-06-08

Abstract excerpt

<h4>Purpose</h4> Pathogenic or likely pathogenic (P/LP) variants are increasingly identified in genes more commonly associated with adult-onset cancer predisposition, but their prevalence and relevance to a child’s presenting cancer remain unclear. <h4>Methods</h4> We retrospectively analyzed 1,280 consecutive pediatric patients with cancer who underwent clinical germline sequencing, using a virtual panel, from...

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Literature Corpus work: bf32844d-9be3-534f-9856-9a9bc2fbeed9
DOI: 10.64898/2026.06.07.26354365

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