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Article

Germline variants observed in pediatric cancer patients related to hereditary breast and ovarian cancer in adults.

International journal of cancer - 15 Dec 2025

Daugs Katharina, Brandes Danielle, Yasin Layal, Anwar Ammarah, Alam Jubayer, Prasad Yash, Bartrina Y Manns Jil, Mescher Melina, Fischer Ute, Borkhardt Arndt, Brozou Triantafyllia, Junk Stefanie V

Abstract excerpt

Genetic predisposition is a major cause of cancer, yet little is known about the role of adult cancer predisposition syndromes (CPSs) in childhood cancers. Although extensively studied in adults, information about the impact of germline variants in genes associated with hereditary breast and ovarian cancer (HBOC) remains scarce in the pediatric context. To elucidate whether (likely) pathogenic variants (LP/PVs)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40857049
DOI: 10.1002/ijc.70097
PMCID: PMC12541558

Genes

TP53
ATM
CHEK2
NBN
NF1
MSH2

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