Germline Mutations in Predisposition Genes in Pediatric Cancer

Abstract excerpt

The prevalence and spectrum of predisposing mutations among children and adolescents with cancer are largely unknown.Knowledge of such mutations may improve the understanding of tumorigenesis, direct patient care, and enable genetic counseling of patients and families. METHODSIn 1120 patients younger than 20 years of age, we sequenced the whole genomes (in 595 patients), whole exomes (in 456), or both (in 69).We...

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