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Article

Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer.

European journal of human genetics : EJHG - 1 Aug 2021

Wagener Rabea, Taeubner Julia, Walter Carolin, Yasin Layal, Alzoubi Deya, Bartenhagen Christoph, Attarbaschi Andishe, Classen Carl-Friedrich, Kontny Udo, Hauer Julia, Fischer Ute, Dugas Martin, Kuhlen Michaela, Borkhardt Arndt, Brozou Triantafyllia

Abstract excerpt

In childhood cancer, the frequency of cancer-associated germline variants and their inheritance patterns are not thoroughly investigated. Moreover, the identification of children carrying a genetic predisposition by clinical means remains challenging. In this single-center study, we performed trio whole-exome sequencing and comprehensive clinical evaluation of a prospectively enrolled cohort of 160 children with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33840814
DOI: 10.1038/s41431-021-00878-x
PMCID: PMC8385053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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