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Article

Germline genetic variants that predispose to myeloproliferative neoplasms and hereditary myeloproliferative phenotypes.

Leukemia research - 1 Nov 2024

Lim Jonathan, Ross David M, Brown Anna L, Scott Hamish S, Hahn Christopher N

Abstract excerpt

Epidemiological evidence of familial predispositions to myeloid malignancies and myeloproliferative neoplasms (MPN) has long been recognised, but recent studies have added to knowledge of specific germline variants in multiple genes that contribute to the familial risk. These variants may be common risk alleles in the general population but have low penetrance and cause sporadic MPN, such as the JAK2 46/1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39316992
DOI: 10.1016/j.leukres.2024.107566

Genes

ATM
DDX41
JAK2
MECOM
RBBP6
RUNX1
SH2B3
TERT

Provenance

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