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Article

Genetics of Myeloproliferative Neoplasms.

Hematology/oncology clinics of North America - 1 Apr 2021

Szybinski Jakub, Meyer Sara C

Abstract excerpt

Myeloproliferative neoplasms are hematopoietic stem cell disorders based on somatic mutations in JAK2, calreticulin, or MPL activating JAK-STAT signaling. Modern sequencing efforts have revealed the genomic landscape of myeloproliferative neoplasms with additional genetic alterations mainly in epigenetic modifiers and splicing factors. High molecular risk mutations with adverse outcomes have been identified and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33641865
DOI: 10.1016/j.hoc.2020.12.002

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