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Article

Genomic heterogeneity in myeloproliferative neoplasms and applications to clinical practice.

Blood reviews - 1 Jul 2020

Lee Joe, Godfrey Anna L, Nangalia Jyoti

Abstract excerpt

The myeloproliferative neoplasms (MPN) polycythaemia vera, essential thrombocythaemia and primary myelofibrosis are chronic myeloid disorders associated most often with mutations in JAK2, MPL and CALR, and in some patients with additional acquired genomic lesions. Whilst the molecular mechanisms downstream of these mutations are now clearer, it is apparent that clinical phenotype in MPN is a product of complex...

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Identifiers

PMID: 32571583
DOI: 10.1016/j.blre.2020.100708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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