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Article

PACAP and VIP Modulate LPS-Induced Microglial Activation and Trigger Distinct Phenotypic Changes in Murine BV2 Microglial Cells.

International journal of molecular sciences - 11 Oct 2021

Karunia Jocelyn, Niaz Aram, Mandwie Mawj, Thomas Broome Sarah, Keay Kevin A, Waschek James A, Al-Badri Ghaith, Castorina Alessandro

Abstract excerpt

Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two structurally related immunosuppressive peptides. However, the underlying mechanisms through which these peptides regulate microglial activity are not fully understood. Using lipopolysaccharide (LPS) to induce an inflammatory challenge, we tested whether PACAP or VIP differentially affected microglial...

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Identifiers

PMID: 34681607
DOI: 10.3390/ijms222010947
PMCID: PMC8535941

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