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Article

Semaphorin 3A-Plexin-A1 signaling through ERK activation is crucial for Toll-like receptor-induced NO production in BV-2 microglial cells.

International journal of molecular medicine - 1 Jun 2014

Ito Takuji, Morita Tokiko, Yoshida Kenji, Negishi Takayuki, Yukawa Kazunori

Abstract excerpt

Semaphorin family members have been identified as axonal guidance molecules that mediate the directional determination for axonal elongation during neuronal development. Several semaphorins have been shown to play crucial roles for various immune response phases. In a previous study using knockout mice, we suggested that Plexin-A1, a Semaphorin 3A (Sema3A) receptor, is involved in the increased production of...

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Identifiers

PMID: 24714875
DOI: 10.3892/ijmm.2014.1727

Genes

TLR4
TNF

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