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Article

A Helminth Protease Inhibitor Modulates the Lipopolysaccharide-Induced Proinflammatory Phenotype of Microglia in vitro.

Neuroimmunomodulation - 1 Jan 2016

Behrendt Peter, Arnold Philipp, Brueck Max, Rickert Uta, Lucius Richard, Hartmann Susanne, Klotz Christian, Lucius Ralph

Abstract excerpt

OBJECTIVE: The aim of this study was to examine whether the natural protease inhibitor Av-cystatin (rAv17) of the parasitic nematode Acanthocheilonema viteae exerts anti-inflammatory effects in an in vitro model of lipopolysaccharide (LPS)-activated microglia. METHODS: Primary microglia were harvested from the brains of 2-day-old Wistar rats and cultured with or without rAv17 (250 nM). After 6 and 24 h the...

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Identifiers

PMID: 27088850
DOI: 10.1159/000444756

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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