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Article

Impact of single amino acid substitution on the structure and function of TANK-binding kinase-1.

Journal of cellular biochemistry - 1 Oct 2021

Umair Mohd, Khan Shama, Mohammad Taj, Shafie Alaa, Anjum Farah, Islam Asimul, Hassan Md Imtaiyaz

Abstract excerpt

Tank-binding kinase 1 (TBK1) is a serine/threonine protein kinase involved in various signaling pathways and subsequently regulates cell proliferation, apoptosis, autophagy, antiviral and antitumor immunity. Dysfunction of TBK1 can cause many complex diseases, including autoimmunity, neurodegeneration, and cancer. This dysfunction of TBK1 may result from single amino acid substitutions and subsequent structural...

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Identifiers

PMID: 34237165
DOI: 10.1002/jcb.30070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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