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Article

Investigating the Influence of Hotspot Mutations in Protein-Protein Interaction of IDH1 Homodimer Protein: A Computational Approach.

Advances in protein chemistry and structural biology - 1 Jan 2018

Thirumal Kumar D, Sneha P, Uppin Jennifer, Usha S, George Priya Doss C

Abstract excerpt

Protein-protein interaction (PPI) helps in maintaining the cellular homeostasis. In particular, the homodimeric proteins play a crucial role as cell regulators. Studying the critical functions of each PPI on the living system is very challenging. The mutations in the PPIs have given birth to various diseases including many types of cancers and it has soon become the target for drug discovery. The mutations in...

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Source

Identifiers

PMID: 29459034
DOI: 10.1016/bs.apcsb.2017.08.002

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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