Article
Eight induced pluripotent stem cell lines (iPSCs) derived from two patients with Leukocyte adhesion deficiency Type I (LAD I) with mutations in the ITGB2 gene.
Stem cell research - 1 Dec 2024
Fekadu-Siebald Julia, Fuchs Nina V, Zahn Stella, Rommel Marcel G E, Schenk Franziska, Huenecke Sabine, Bremm Melanie, Kreyenberg Hermann, Kuci Zyrafete, Jacobsen Eva-Maria, Hoenig Manfred, Schwarz Klaus, Bader Peter, Modlich Ute, König Renate, Bakhtiar Shahrzad
Abstract excerpt
Leukocyte Adhesion Deficiency Type I (LAD I) is a rare inborn error of immunity caused by mutations in the ITGB2 gene coding for β2-integrin CD18 on the surface of leukocytes. Affected patients display severe clinical manifestations with life threatening infections and inflammatory complications due to an impaired ability of leukocytes to transmigrate from the blood vessel to the tissue. Here we describe the...
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