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Article

PBX1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm.

Stem cell reports - 9 Nov 2021

Muggeo Sharon, Crisafulli Laura, Uva Paolo, Fontana Elena, Ubezio Marta, Morenghi Emanuela, Colombo Federico Simone, Rigoni Rosita, Peano Clelia, Vezzoni Paolo, Della Porta Matteo Giovanni, Villa Anna, Ficara Francesca

Abstract excerpt

PBX1 regulates the balance between self-renewal and differentiation of hematopoietic stem cells and maintains proto-oncogenic transcriptional pathways in early progenitors. Its increased expression was found in myeloproliferative neoplasm (MPN) patients bearing the JAK2V617F mutation. To investigate if PBX1 contributes to MPN, and to explore its potential as therapeutic target, we generated the JP mouse strain,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34678207
DOI: 10.1016/j.stemcr.2021.09.016
PMCID: PMC8581051

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