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Article

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells.

Blood - 26 Dec 2019

Mansier Olivier, Kilani Badr, Guitart Amélie V, Guy Alexandre, Gourdou-Latyszenok Virginie, Marty Caroline, Parrens Marie, Plo Isabelle, Vainchenker William, James Chloé

Abstract excerpt

The major weakness of most knock-in JAK2V617F mouse models is the presence of the JAK2 mutation in all rather than in a few hematopoietic stem cells (HSC), such as in human "early-stage" myeloproliferative neoplasms (MPN). Understanding the mechanisms of disease initiation is critical as underscored by the incidence of clonal hematopoiesis of indeterminate potential associated with JAK2V617F. Currently, such...

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Identifiers

PMID: 31697834
DOI: 10.1182/blood.2019001163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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