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Article

The ParaHox gene Cdx4 induces acute erythroid leukemia in mice.

Blood advances - 26 Nov 2019

Thoene Silvia, Mandal Tamoghna, Vegi Naidu M, Quintanilla-Martinez Leticia, Rösler Reinhild, Wiese Sebastian, Metzeler Klaus H, Herold Tobias, Haferlach Torsten, Döhner Konstanze, Döhner Hartmut, Schwarzmüller Luisa, Klingmüller Ursula, Buske Christian, Rawat Vijay P S, Feuring-Buske Michaela

Abstract excerpt

Acute erythroid leukemia (AEL) is a rare and aggressive form of acute leukemia, the biology of which remains poorly understood. Here we demonstrate that the ParaHox gene CDX4 is expressed in patients with acute erythroid leukemia, and that aberrant expression of Cdx4 induced homogenously a transplantable acute erythroid leukemia in mice. Gene expression analyses demonstrated upregulation of genes involved in...

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Identifiers

PMID: 31770439
DOI: 10.1182/bloodadvances.2019000761
PMCID: PMC6880902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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