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Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages.

Molecular immunology - 1 Dec 2021

Cao Sijia, Dou Xiaoyun, Zhang Xuemei, Fang Yuting, Yang Zihan, Jiang Yinting, Hao Xiaoling, Zhang Ziyuan, Wang Hong

Abstract excerpt

Interferon stimulated gene 15 (ISG15) is one of the most robustly upregulated interferon stimulated genes (ISGs) and also a ubiquitin-like modifier which has been reported to play an important role in host defense against pathogens. Cytosolic nucleic acids detected by DNA sensors induce type Ⅰ interferons (IFN-Ⅰs) and ISGs in host cells. Streptococcus pneumoniae (S. pn) autolysin LytA triggers bacterial lysis and...

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Identifiers

PMID: 34673375
DOI: 10.1016/j.molimm.2021.09.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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