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Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer’s disease model mice

23 Jan 2024

Abstract excerpt

The gut microbiota (GM) and its metabolites affect the host nervous system and are involved in the pathogeneses of various neurological diseases. However, the specific GM alterations under pathogenetic pressure and their contributions to the “microbiota – metabolite – brain axis” in Alzheimer’s disease (AD) remain unclear. Here, we investigated the GM and the fecal, serum, cortical metabolomes in APP/PS1 and...

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PMID: 38261437
DOI: 10.1080/19490976.2024.2302310

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