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Gut microbiome compositional and functional features associate with Alzheimer's disease pathology

1 Jul 2025

Abstract excerpt

BACKGROUND: The gut microbiome is a potentially modifiable risk factor for Alzheimer's disease (AD); however, understanding of its composition and function regarding AD pathology is limited. METHODS: Shallow-shotgun metagenomics was used to analyze the fecal microbiome of participants in the Wisconsin Microbiome in Alzheimer's Risk Study, leveraging clinical data and cerebrospinal fluid (CSF) biomarkers....

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PMID: 40604345
DOI: 10.1002/alz.70417

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