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Article

Improvement of 2-phenylethanol production in Saccharomyces cerevisiae by evolutionary and rational metabolic engineering.

PloS one - 1 Jan 2021

Zhu Linghuan, Xu Sha, Li Youran, Shi Guiyang

Abstract excerpt

2-Phenylethanol (2-PE) is a valuable aromatic compound with favorable flavors and good properties, resulting in its widespread application in the cosmetic, food and medical industries. In this study, a mutant strain, AD032, was first obtained by adaptive evolution under 2-PE stress. Then, a fusion protein from the Ehrlich pathway, composed of tyrB from Escherichia coli, kdcA from Lactococcus lactis and ADH2 from...

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Identifiers

PMID: 34665833
DOI: 10.1371/journal.pone.0258180
PMCID: PMC8525735

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