Article
Evolutionary and reverse engineering in Saccharomyces cerevisiae reveals a Pdr1p mutation-dependent mechanism for 2-phenylethanol tolerance.
Microbial cell factories - 23 Dec 2022
Xia Huili, Kang Yue, Ma Zilin, Hu Cuiyu, Yang Qiao, Zhang Xiaoling, Yang Shihui, Dai Jun, Chen Xiong
Abstract excerpt
BACKGROUND: 2-Phenylethanol (2-PE), a higher alcohol with a rose-like odor, inhibits growth of the producer strains. However, the limited knowledge regarding 2-PE tolerance mechanisms renders our current knowledge base insufficient to inform rational design. RESULTS: To improve the growth phenotype of Saccharomyces cerevisiae under a high 2-PE concentration, adaptive laboratory evolution (ALE) was used to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.