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Mutagenesis and Analysis for Enhancing (2R,3R)-2,3-Butanediol Tolerance and Production in Corynebacterium glutamicum.

Molecules (Basel, Switzerland) - 4 Aug 2026

Liu Zilong, Cui Haoran, Jiang Yuxuan, Wang Zhiwen, Chen Tao

Abstract excerpt

2,3-Butanediol (2,3-BD) is a versatile bulk chemical, serving as a high-boiling green solvent, a key monomer for polyesters and polyurethanes, and a crucial intermediate in the production of fine chemicals and cosmetics. Additionally, it is a key intermediate for pharmaceuticals and agrochemicals, supporting green chemistry. Microbial production of 2,3-BD offers a sustainable bioprocess but faces the challenge of...

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Corynebacterium glutamicum
Fermentation
Metabolic Engineering
Mutagenesis
Mutation

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PMID: 42588560
DOI: 10.3390/molecules31152714
PMCID: PMC13467605

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