Article
Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence.
Nature genetics - 1 Nov 2021
Moody Sarah, Senkin Sergey, Islam S M Ashiqul, Wang Jingwei, Nasrollahzadeh Dariush, Cortez Cardoso Penha Ricardo, Fitzgerald Stephen, Bergstrom Erik N, Atkins Joshua, He Yudou, Khandekar Azhar, Smith-Byrne Karl, Carreira Christine, Gaborieau Valerie, Latimer Calli, Thomas Emily, Abnizova Irina, Bucciarelli Pauline E, Jones David, Teague Jon W, Abedi-Ardekani Behnoush, Serra Stefano, Scoazec Jean-Yves, Saffar Hiva, Azmoudeh-Ardalan Farid, Sotoudeh Masoud, Nikmanesh Arash, Poustchi Hossein, Niavarani Ahmadreza, Gharavi Samad, Eden Michael, Richman Paul, Campos Lia S, Fitzgerald Rebecca C, Ribeiro Luis Felipe, Soares-Lima Sheila Coelho, Dzamalala Charles, Mmbaga Blandina Theophil, Shibata Tatsuhiro, Menya Diana, Goldstein Alisa M, Hu Nan, Malekzadeh Reza, Fazel Abdolreza, McCormack Valerie, McKay James, Perdomo Sandra, Scelo Ghislaine, Chanudet Estelle, Humphreys Laura, Alexandrov Ludmil B, Brennan Paul, Stratton Michael R
Abstract excerpt
Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that is not fully explained by known lifestyle and environmental risk factors. It has been speculated that an unknown exogenous exposure(s) could be responsible. Here we combine the fields of mutational signature analysis with cancer epidemiology to study 552 ESCC genomes from eight countries with varying incidence rates. Mutational...
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