Article
Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.
Gastroenterology - 1 May 2016
Sawada Genta, Niida Atsushi, Uchi Ryutaro, Hirata Hidenari, Shimamura Teppei, Suzuki Yutaka, Shiraishi Yuichi, Chiba Kenichi, Imoto Seiya, Takahashi Yusuke, Iwaya Takeshi, Sudo Tomoya, Hayashi Tomoatsu, Takai Hiroki, Kawasaki Yoshihiro, Matsukawa Takashi, Eguchi Hidetoshi, Sugimachi Keishi, Tanaka Fumiaki, Suzuki Hiromichi, Yamamoto Ken, Ishii Hideshi, Shimizu Makiko, Yamazaki Hiroshi, Yamazaki Makoto, Tachimori Yuji, Kajiyama Yoshiaki, Natsugoe Shoji, Fujita Hiromasa, Mafune Kenichi, Tanaka Yoichi, Kelsell David P, Scott Claire A, Tsuji Shoji, Yachida Shinichi, Shibata Tatsuhiro, Sugano Sumio, Doki Yuichiro, Akiyama Tetsu, Aburatani Hiroyuki, Ogawa Seishi, Miyano Satoru, Mori Masaki, Mimori Koshi
Abstract excerpt
BACKGROUND & AIMS: Esophageal squamous cell carcinoma (ESCC) is the predominant form of esophageal cancer in Japan. Smoking and drinking alcohol are environmental risk factors for ESCC, whereas single nucleotide polymorphisms in ADH1B and ALDH2, which increase harmful intermediates produced by drinking alcohol, are genetic risk factors. We conducted a large-scale genomic analysis of ESCCs from patients in Japan...
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