Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis.

JCI insight - 6 Oct 2016

Liu Wenjin, Snell Jeff M, Jeck William R, Hoadley Katherine A, Wilkerson Matthew D, Parker Joel S, Patel Nirali, Mlombe Yohannie B, Mulima Gift, Liomba N George, Wolf Lindsey L, Shores Carol G, Gopal Satish, Sharpless Norman E

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) is endemic in regions of sub-Saharan Africa (SSA), where it is the third most common cancer. Here, we describe whole-exome tumor/normal sequencing and RNA transcriptomic analysis of 59 patients with ESCC in Malawi. We observed similar genetic aberrations as reported in Asian and North American cohorts, including mutations of TP53, CDKN2A, NFE2L2, CHEK2, NOTCH1, FAT1, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Esophageal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Squamous Cell Carcinoma

Share to Gene Dosage

Share to Malawi

Share to Transcriptome

Share to Tumor Suppressor Protein p53

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27734031
DOI: 10.1172/jci.insight.88755
PMCID: PMC5053149

Genes

CHEK2
FAT1
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis.PMID 27734031Read ↗

Exome sequencing identifies novel somatic variants in African American esophageal squamous cell carcinoma.Semantic proximity Read ↗

Genetic landscape of esophageal squamous cell carcinoma.Semantic proximity Read ↗

Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence.Semantic proximity Read ↗

Epidemiology of Esophageal Squamous Cell Carcinoma.Semantic proximity Read ↗

Comprehensive Analyses Reveal Effects on Tumor Immune Infiltration and Immunotherapy Response of APOBEC Mutagenesis and Its Molecular Mechanisms in Esophageal Squamous Cell CarcinomaSemantic proximity Read ↗

Mutational signatures in esophageal squamous cell carcinoma from eight countries of varying incidenceSemantic proximity Read ↗

Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomasSemantic proximity Read ↗

The mutational landscape of head and neck squamous cell carcinoma.Semantic proximity Read ↗

Novel Aberrations Uncovered in Barrett's Esophagus and Esophageal Adenocarcinoma Using Whole Transcriptome Sequencing.Semantic proximity Read ↗

Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma.Semantic proximity Read ↗

Integrated Multi-omics Reveals Key Molecular Drivers and Therapeutic Strategies in a Spontaneous Cutaneous Squamous Cell Carcinoma Model of MacaquesSemantic proximity Read ↗

Whole-exome Sequencing in Penile Squamous Cell Carcinoma Uncovers Novel Prognostic Categorization and Drug Targets Similar to Head and Neck Squamous Cell Carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.