Article
Dual-function enzyme catalysis for enantioselective carbon-nitrogen bond formation.
Nature chemistry - 1 Dec 2021
Liu Zhen, Calvó-Tusell Carla, Zhou Andrew Z, Chen Kai, Garcia-Borràs Marc, Arnold Frances H
Abstract excerpt
Chiral amines can be made by insertion of a carbene into an N-H bond using two-catalyst systems that combine a transition metal-based carbene-transfer catalyst and a chiral proton-transfer catalyst to enforce stereocontrol. Haem proteins can effect carbene N-H insertion, but asymmetric protonation in an active site replete with proton sources is challenging. Here we describe engineered cytochrome P450 enzymes...
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