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Article

Flavin-dependent halogenases catalyze enantioselective olefin halocyclization.

Nature communications - 1 Jun 2021

Mondal Dibyendu, Fisher Brian F, Jiang Yuhua, Lewis Jared C

Abstract excerpt

Halocyclization of alkenes is a powerful bond-forming tool in synthetic organic chemistry and a key step in natural product biosynthesis, but catalyzing halocyclization with high enantioselectivity remains a challenging task. Identifying suitable enzymes that catalyze enantioselective halocyclization of simple olefins would therefore have significant synthetic value. Flavin-dependent halogenases (FDHs) catalyze...

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Identifiers

PMID: 34075034
DOI: 10.1038/s41467-021-23503-3
PMCID: PMC8169660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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