Article
Unlocking the function promiscuity of old yellow enzyme to catalyze asymmetric Morita-Baylis-Hillman reaction.
Nature communications - 9 Jul 2024
Wang Lei, Wu Yaoyun, Hu Jun, Yin Dejing, Wei Wanqing, Wen Jian, Chen Xiulai, Gao Cong, Zhou Yiwen, Liu Jia, Hu Guipeng, Li Xiaomin, Wu Jing, Zhou Zhi, Liu Liming, Song Wei
Abstract excerpt
Exploring the promiscuity of native enzymes presents a promising strategy for expanding their synthetic applications, particularly for catalyzing challenging reactions in non-native contexts. In this study, we explore the promiscuous potential of old yellow enzymes (OYEs) to facilitate the Morita-Baylis-Hillman reaction (MBH reaction), leveraging substrate similarities between MBH reaction and reduction reaction....
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