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Article

Enantioselective Synthesis of α-Trifluoromethyl Amines via Biocatalytic N-H Bond Insertion with Acceptor-Acceptor Carbene Donors.

Journal of the American Chemical Society - 16 Feb 2022

Nam Donggeon, Tinoco Antonio, Shen Zhuofan, Adukure Ronald D, Sreenilayam Gopeekrishnan, Khare Sagar D, Fasan Rudi

Abstract excerpt

The biocatalytic toolbox has recently been expanded to include enzyme-catalyzed carbene transfer reactions not occurring in Nature. Herein, we report the development of a biocatalytic strategy for the synthesis of enantioenriched α-trifluoromethyl amines through an asymmetric N-H carbene insertion reaction catalyzed by engineered variants of cytochrome c552 from Hydrogenobacter thermophilus. Using a combination...

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Identifiers

PMID: 35107997
DOI: 10.1021/jacs.1c10750
PMCID: PMC8855427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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