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Article

TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis.

Nature communications - 18 Oct 2021

Tulstrup Morten, Soerensen Mette, Hansen Jakob Werner, Gillberg Linn, Needhamsen Maria, Kaastrup Katja, Helin Kristian, Christensen Kaare, Weischenfeldt Joachim, Grønbæk Kirsten

Abstract excerpt

Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS). Here, we investigate associations between TET2 mutations and DNA methylation in whole blood in 305 elderly twins, 15 patients with CCUS and 18 healthy controls. We find that TET2 mutations are associated with DNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to DNA Methyltransferase 3A

Share to Enhancer Elements, Genetic

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Source

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Identifiers

PMID: 34663818
DOI: 10.1038/s41467-021-26093-2
PMCID: PMC8523747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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