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AML/T cell interactomics uncover correlates of patient outcomes and the key role of ICAM1 in T cell killing of AML

9 May 2024

Abstract excerpt

Abstract T cells are important for the control of acute myeloid leukemia (AML), a common and often deadly malignancy. We observed that some AML patient samples are resistant to killing by human-engineered cytotoxic CD4 + T cells. Single-cell RNA-seq of primary AML samples and CD4 + T cells before and after their interaction uncovered transcriptional programs that correlate with AML sensitivity or resistance to...

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PMID: 38724673
DOI: 10.1038/s41375-024-02255-1

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