Article
Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis.
PLoS pathogens - 1 Oct 2021
Earle Sarah G, Lobanovska Mariya, Lavender Hayley, Tang Changyan, Exley Rachel M, Ramos-Sevillano Elisa, Browning Douglas F, Kostiou Vasiliki, Harrison Odile B, Bratcher Holly B, Varani Gabriele, Tang Christoph M, Wilson Daniel J, Maiden Martin C J
Abstract excerpt
Many invasive bacterial diseases are caused by organisms that are ordinarily harmless components of the human microbiome. Effective interventions against these microbes require an understanding of the processes whereby symbiotic or commensal relationships transition into pathology. Here, we describe bacterial genome-wide association studies (GWAS) of Neisseria meningitidis, a common commensal of the human...
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