Article
High-throughput phenotype-to-genotype testing of meningococcal carriage and disease isolates detects genetic determinants of disease-relevant phenotypic traits.
mBio - 11 Dec 2024
Farzand Robeena, Kimani Mercy W, Mourkas Evangelos, Jama Abdullahi, Clark Jack L, De Ste Croix Megan, Monteith William M, Lucidarme Jay, Oldfield Neil J, Turner David P J, Borrow Ray, Martinez-Pomares Luisa, Sheppard Samuel K, Bayliss Christopher D
Abstract excerpt
Genome-wide association studies (GWAS) with binary or single phenotype data have successfully identified disease-associated genotypes and determinants of antimicrobial resistance. We describe a novel phenotype-to-genotype approach for a major bacterial pathogen that involves simultaneously testing for associations among multiple disease-related phenotypes and linkages between phenotypic variation and genetic...
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