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Article

Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility.

eLife - 23 Dec 2014

Caesar Joseph J E, Lavender Hayley, Ward Philip N, Exley Rachel M, Eaton Jack, Chittock Emily, Malik Talat H, Goiecoechea De Jorge Elena, Pickering Matthew C, Tang Christoph M, Lea Susan M

Abstract excerpt

Genome-wide association studies have found variation within the complement factor H gene family links to host susceptibility to meningococcal disease caused by infection with Neisseria meningitidis (Davila et al., 2010). Mechanistic insights have been challenging since variation within this locus is complex and biological roles of the factor H-related proteins, unlike factor H, are incompletely understood. N....

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Share to Amino Acid Sequence
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Proteins

Share to Complement Factor H

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Share to Meningitis, Bacterial

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Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 25534642
DOI: 10.7554/eLife.04008
PMCID: PMC4273445

Genes

CFH
CFHR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility.PMID 25534642Read ↗

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The Meningococcal Vaccine Candidate Neisserial Surface Protein A (NspA) Binds to Factor H and Enhances Meningococcal Resistance to ComplementSemantic proximity Read ↗

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