Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein.

PloS one - 1 Jan 2015

Bradley Declan T, Bourke Thomas W, Fairley Derek J, Borrow Raymond, Shields Michael D, Zipfel Peter F, Hughes Anne E

Abstract excerpt

BACKGROUND: Neisseria meningitidis can cause severe infection in humans. Polymorphism of Complement Factor H (CFH) is associated with altered risk of invasive meningococcal disease (IMD). We aimed to find whether polymorphism of other complement genes altered risk and whether variation of N. meni...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Bacterial
Share to Complement Factor H
Share to Complement System Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Membrane Cofactor Protein

Share to Meningococcal Infections

Share to Neisseria meningitidis

Share to Recurrence

Source

Open in PubMed Open full text

Identifiers

PMID: 25798599
DOI: 10.1371/journal.pone.0120757
PMCID: PMC4370764

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25798599-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein.PMID 25798599Read ↗

Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease.Semantic proximity Read ↗

Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis.Semantic proximity Read ↗

Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccinesSemantic proximity Read ↗

Polymorphisms affecting expression of the vaccine antigen factor H binding protein influence invasiveness of Neisseria meningitidisSemantic proximity Read ↗

Human genetics of meningococcal infections.Semantic proximity Read ↗

Factor H, a regulator of complement activity, is a major determinant of meningococcal disease susceptibility in UK Caucasian patients.Semantic proximity Read ↗

Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations.Semantic proximity Read ↗

Confirmation of Host Genetic Determinants in the CFH Region and Susceptibility to Meningococcal Disease in a Central European Study Sample.Semantic proximity Read ↗

Complement Factor H related proteins and their biological role during bacterial infectionSemantic proximity Read ↗

Genetic susceptibility to meningococcal infection.Semantic proximity Read ↗

Differences between culture & non-culture confirmed invasive meningococci with a focus on factor H-binding protein distribution.Semantic proximity Read ↗

Meningococcal factor H binding protein as immune evasion factor and vaccine antigenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.