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Article

Functional Significance of Factor H Binding to Neisseria meningitidis

1 Jun 2006

Abstract excerpt

Neisseria meningitidis is an important cause of septicemia and meningitis. To cause disease, the bacterium must successfully survive in the bloodstream where it has to avoid being killed by host innate immune mechanisms, particularly the complement system. A number of pathogenic microbes bind factor H (fH), the negative regulator of the alternative pathway of complement activation, to promote their survival in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16751403
DOI: 10.4049/jimmunol.176.12.7566

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