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Meningococcal factor H binding protein as immune evasion factor and vaccine antigen

16 Apr 2020

Abstract excerpt

Factor H binding protein (fHbp) is a key virulence factor of Neisseria meningitidis and a main component of the two licensed vaccines against serogroup B meningococcus (Bexsero and Trumenba). fHbp is a surface-exposed lipoprotein that enables the bacterium to survive in human blood by binding the human complement regulator factor H (fH). When used as vaccine, the protein induces antibodies with potent...

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PMID: 32298465
DOI: 10.1002/1873-3468.13793

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