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Article

Generating a new mouse model for nuclear PTEN deficiency by a single K13R mutation.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2021

Kato Takashi, Igarashi Atsushi, Sesaki Hiromi, Iijima Miho

Abstract excerpt

Many human diseases, including cancer and neurological abnormalities, are linked to deficiencies of phosphatase and tensin homolog deleted on chromosome ten (PTEN), a dual phosphatase that dephosphorylates both lipids and proteins. PTEN functions in multiple intracellular locations, including the plasma membrane and nucleus. Therefore, a critical challenge to understand the pathogenesis of PTEN-associated...

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Identifiers

PMID: 34661323
DOI: 10.1111/gtc.12902
PMCID: PMC8678295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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