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Article

Development and Characterization of NEX-Pten, a Novel Forebrain Excitatory Neuron-Specific Knockout Mouse

1 Jan 2012

Abstract excerpt

The phosphatase and tensin homolog located on chromosome 10 (PTEN) suppresses the activity of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin (mTOR) pathway, a signaling cascade critically involved in the regulation of cell proliferation and growth. Human patients carrying germ line PTEN mutations have an increased predisposition to tumors, and also display a variety of neurological symptoms and...

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PMID: 22572802
DOI: 10.1159/000337229

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Related research

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Development and Characterization of NEX-Pten, a Novel Forebrain Excitatory Neuron-Specific Knockout MousePMID 22572802Read ↗

Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes.Semantic proximity Read ↗

Function of PTEN during the formation and maintenance of neuronal circuits in the brain.Semantic proximity Read ↗

PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypesSemantic proximity Read ↗

Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.Semantic proximity Read ↗

The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and functionSemantic proximity Read ↗

Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids.Semantic proximity Read ↗

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos diseaseSemantic proximity Read ↗

The mTOR pathway genes <i>mTOR</i> , <i>Rheb</i> , <i>Depdc5</i> , <i>Pten</i> , and <i>Tsc1</i> have convergent and divergent impacts on cortical neuron development and functionSemantic proximity Read ↗

Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.Semantic proximity Read ↗

PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors.Semantic proximity Read ↗

Pten regulates neuronal arborization and social interaction in mice.Semantic proximity Read ↗

PTEN deletion increases hippocampal granule cell excitability in male and female miceSemantic proximity Read ↗

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